TY - JOUR
T1 - The clinical value and cost effectiveness of a 6-month digital health intervention to improve physical activity and mental health-related quality of life in people with chronic kidney disease (Kidney BEAM)
AU - Greenwood, Sharlene A.
AU - Briggs, Juliet
AU - Walkin, Christy
AU - Mangahis, Emmanuel
AU - Young, Hannah
AU - Castle, Ellen
AU - Billany, Roseanne
AU - Asgari, Elham
AU - Bhandari, Sunil
AU - Bishop, Nicolette
AU - Bramham, Kate
AU - Burton, James
AU - Campbell, Jackie
AU - Chilcot, Joseph
AU - Cooper, Nicola
AU - Deelchand, Vashist
AU - Graham-Brown, Matthew
AU - Haggis, Lynda
AU - Hamilton, Alexander
AU - Jesky, Mark
AU - Kalra, Philip
AU - Koufaki, Pelagia
AU - McCafferty, Kieran
AU - Nixon, Andrew
AU - Noble, Helen
AU - Saynor, Zoe
AU - Taal, Maarten
AU - Tollitt, James
AU - Wheeler, David
AU - Wilkinson, Thomas
AU - Worboys, Hannah
AU - Macdonald, Jamie
PY - 2024/8/27
Y1 - 2024/8/27
N2 - There is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention in CKD. In a single-blind, 11 centre, randomised controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity digital health intervention or a waitlist control. The primary outcomes were the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6 months, and cost-effectiveness. At 6 months there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 {95% confidence interval: 4.4 to 7.5} arbitrary units, p<0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness to pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. In conclusion, the Kidney BEAM physical activity digital health intervention is a clinically valuable and cost-effective means to improve mental health related quality of life in people with CKD (trial registration no. NCT04872933).
AB - There is inequity in provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention in CKD. In a single-blind, 11 centre, randomised controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity digital health intervention or a waitlist control. The primary outcomes were the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6 months, and cost-effectiveness. At 6 months there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 {95% confidence interval: 4.4 to 7.5} arbitrary units, p<0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness to pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. In conclusion, the Kidney BEAM physical activity digital health intervention is a clinically valuable and cost-effective means to improve mental health related quality of life in people with CKD (trial registration no. NCT04872933).
KW - Chronic kidney disease
KW - Digital health intervention
KW - RCT
KW - Cost-effectiveness
KW - Physical activity
KW - Quality of life
M3 - Article
SN - 2468-0249
JO - Kidney International Reports
JF - Kidney International Reports
ER -
